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Altered vascular endothelial control of facial skin blood flow in rosacea
Author(s) -
MetzlerWilson Kristen,
Kube Megan,
Mann Sarah,
Demidova Olga,
Sammons Dawn L,
Wilson Thad E
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.736.3
Subject(s) - forehead , rosacea , laser doppler velocimetry , vasodilation , medicine , cheek , nitric oxide , endocrinology , blood flow , anesthesia , cardiology , anatomy , dermatology , acne
Sympathetic outflow to the face may be augmented in rosacea, a disorder which clinically presents with flushing (Metzler‐Wilson & Toma, et al , J Neurophysiol , 2015). To determine whether regulatory mechanisms of skin blood flow (SkBF) are altered by these chronic outflow differences or associated inflammatory mediators, SkBF oscillations were assessed in 9 otherwise healthy subjects with rosacea and age‐sex matched controls during baseline and local heat stress (42°C, 30 min). Local heating is classified as a flushing trigger in rosacea and induces cutaneous vasodilation with an initial axon reflex‐mediated peak and a second nitric oxide‐mediated peak. We hypothesized that compared to controls, individuals with rosacea would demonstrate greater changes in spectral power in the vascular endothelial (very‐low frequency (VLF); 0.009–0.02 Hz) and sympathetic (low frequency (LF); 0.02–0.06 Hz) frequency ranges during heating of typically rosacea‐affected (forehead, cheek) but not rosacea‐unaffected (forearm, palm) skin areas. SkBF (laser‐Doppler flowmetry) was measured and changes in SkBF spectral power (fast Fourier transform) in VLF and LF ranges from baseline to heating were determined at each skin site. Individuals with rosacea had significantly greater changes in VLF SkBF spectral power in cheek (0.024±0.003 vs. 0.006±0.002 au; p=0.03) and forehead (0.030±0.003 vs. 0.011±0.001 au; p=0.04) but not forearm (0.015±0.002 vs. 0.013±0.001 au; p=0.76) or palm (−0.019±0.006 vs. −0.041±0.005 au, rosacea and control, respectively; p=0.38) sites. There were no significant differences in the change in LF SkBF spectral power between groups (cheek p=0.29, forehead p=0.35, forearm p=0.69, palm p=0.80). These data indicate that during local heat stress, individuals with rosacea have altered vascular endothelial control of facial SkBF. These vascular endothelial differences may be due to chronic neuroinflammatory processes. Support or Funding Information National Rosacea Society