Premium
Mitigation of Diazinon‐induced cardiovascular and renal dysfunction by Gallic acid
Author(s) -
Ajibade Tayo,
Oyagbemi Ademola A.,
Omobowale Temidayo O,
Olowu Ebunoluwa R
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.732.4
Subject(s) - diazinon , gallic acid , malondialdehyde , oxidative stress , superoxide dismutase , glutathione peroxidase , chemistry , glutathione , catalase , antioxidant , medicine , endocrinology , nitric oxide , pharmacology , biochemistry , biology , enzyme , pesticide , agronomy
The link between environmental pollutants and cardiovascular dysfunction had been neglected for the decades. However, new insights into the pathology and the consequences of these killers are being studied. In this study, rats were divided into four groups each containing 10 rats. Rats in group one served as controls and were administered normal saline, whereas rats in group two were orally gavaged with 3 mg/kg of Diazinon (DZN) alone for twenty one consecutive days. The rats in groups 3 and 4 were administered with 60 mg/kg and 120 mg/kg Gallic acid (GA) in addition to DZN for twenty one consecutive days. Exposure of rats to Diazinon significantly (p <0.05) reduced the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione‐S‐transferase (GST) activities and reduced glutathione (GSH) content. Also, malondialdehyde, hydrogen peroxide (H2O2) generated and nitric oxide (NO) contents were also significantly (p <0.05) elevated following DZN exposure. DZN also caused significant (p <0.05) decreased heart rate and QT prolongation. Haematological analysis revealed significant reduction (p< 0.05) in packed cell volume (PCV), Haemoglobin concentration (Hb), red blood cell (RBC) count, total white blood cell counts of rats administered only DZN. Observations in this study suggest a protective modulatory role for Gallic acid in Diazinon‐induced anaemia and associated cardiovascular dysfunction in rats. Treatment with Gallic acid reversed the aforementioned oxidative stress markers, increased antioxidant defence system and the deleterious effects on haematological parameters of rats. Pathology of the heart and kidney was also restored.