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Myocardium From the Left and Right Ventricles of Human Hearts Have Similar Mechanical Properties
Author(s) -
Blair Cheavar A,
Guglin Maya,
Stromberg Arnold,
Campbell Kenneth S
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.732.1
Subject(s) - ventricle , heart failure , left ventricles , cardiology , medicine , isometric exercise , human heart , cardiac ventricle , myocyte , anatomy
The left and right ventricles (LV and RV) of human hearts generate different pressures. It is not clear if this difference in pressure reflects the arrangement of cells in each ventricle, or the force generating capacity of individual myocytes. Thus, the aim of this study is to test the hypothesis that cells from the RV and LV of human hearts have different mechanical properties. Chemically permeabilized multicellular preparations from both ventricles of explanted hearts from patients with heart failure (n=12) and patients without a history of heart failure (non‐failing samples) (n=6) were attached between a force transducer and a motor to determine mechanical properties. Similar to prior data from our laboratory, heart failure reduced isometric force and maximum power by ~40% (p<0.001) and ~30% (p=0.004) respectively. Heart failure also increased pCa 50 from ~5.41 to ~5.55 (p=0.006). None of these properties differed between the LV and the RV samples (all p‐values > 0.05). There were no significant interactions between heart failure status and region. These data imply that myocardium from the left and right ventricles has comparable mechanical properties and that heart failure impacts both ventricles in a similar way. Interventricular differences in chamber function are most likely to reflect structural effects as opposed to the intrinsic contractile properties of the cells. Support or Funding InformationNIH 8UL1TR000117‐02 NIH P30GM110787 AHA 15GRNT25460003 NSF 153854