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Experimentally‐ induced chronic kidney disease in rats, and the influence of curcumin thereon
Author(s) -
Ali Badreldin H.,
AlSalam Suhail,
Al Za'abi Mohamed H.,
Al Suleminai Yousif,
Nemmar Abderrahim
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.711.8
Subject(s) - curcumin , oxidative stress , creatinine , chemistry , pharmacology , antioxidant , nephrotoxicity , kidney , superoxide dismutase , glutathione , kidney disease , lipocalin , inflammation , renal function , catalase , albumin , endocrinology , medicine , biochemistry , enzyme
Curcumin (a natural phenolic yellow pigment isolated from turmeric) has several pharmacological properties that include antioxidant, anti‐inflammatory and antiapoptotic activities. Here, we investigated some effects of three graded oral doses of curcumin (37.5, 75 and 150 mg/kg) for 35 days on kidney structure and function in rats with chronic kidney disease (CKD) induced by adenine (0.25% w/w in feed for 35 days), which is known to involve inflammation, oxidative stress and apoptosis. Using several indices in plasma, urine and kidney homogenates, adenine was found to lower creatinine clearance and increase plasma concentrations of creatinine, urea, neutrophil gelatinase‐associated lipocalin and N‐Acetyl‐beta‐D‐glucosaminidase activity. Furthermore, it raised plasma concentrations of the uremic toxin indoxyl sulfate, some inflammatory cytokines and urinary albumin concentration. Renal morphology was severely damaged and histopathological markers of inflammation and fibrosis were especially increased. In renal homogenates, antioxidant indices, including superoxide dismutase and catalase activities, total antioxidant capacity and reduced glutathione were all adversely affected. Most of these adenine ‐ induced actions were moderately and dose ‐dependently mitigated by curcumin, especially at the highest dose. Curcumin did not cause any overt adverse effect on the treated rats. The results suggest that different doses of curcumin produce variable salutary effects against adenine‐induced CKD in rats, and that, pending further pharmacological and toxicological studies, its usability as a possible ameliorative agent in human CKD should be considered. Support or Funding Information This work was funded by the Research Council, Oman (RC/MED/PHAR/13/01)