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Co‐ultra PEALut enhances neuronal recovery after a moderate traumatic brain injury
Author(s) -
Campolo Michela,
Crupi Rosalia,
Cordaro Marika,
Bruschetta Giuseppe,
Siracusa Rosalba,
Esposito Emanuela,
Cuzzocrea Salvatore
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.706.8
Subject(s) - traumatic brain injury , neurogenesis , hippocampal formation , medicine , neurotrophic factors , neuroscience , hippocampus , morris water navigation task , doublecortin , neuroprotection , pharmacology , dentate gyrus , psychology , psychiatry , receptor
Traumatic brain injury (TBI) is a major health problem worldwide. Currently, there is no effective treatment to improve neural structural repair and functional recovery. Recently, has been demonstrated that hippocampal injury‐induced neurogenesis is one mechanism underlying endogenous repair following TBI. The aim of this study was to evaluate the neuro‐regenerative properties co‐ultra PEALut (constituted by the association of palmitoylethanolamide (PEA), with the flavonoid luteolin (Lut) in a mouse model of TBI until 7 days. TBI was induced in mice by the controlled cortical impact (CCI), one of the most common models of TBI; the mice were orally administered co‐ultra PEALut (1mg/Kg) 1h after trauma and daily for 72h and 7d. A conspicuously neurogenesis was seen in mice 72h and 7d after trauma. Co‐ultra PEALut treatment stimulated neuronal reconstitution process restoring the basal level of new neurons (by BrdU staining) and mature neurons (by doublecortin staining). Moreover this positive effect was associated with an important upregulation of neurotrophic factors (BDNF and NT‐3), ultimately leading to improvement in memory recall on behavioral testing (Morris water maze test). Co‐ultra PEALut could represent a therapeutic potential of augmenting the endogenous repair response for treating TBI.