Premium
Effects of Raspberry Dietary Supplementation on Risk Biomarkers of Diabetes Related Complications and Heart Disease in Diabetic Mice
Author(s) -
Noratto Giuliana,
Chew Boon,
Mencia Alejandra
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.692.23
Subject(s) - resistin , blowing a raspberry , medicine , endocrinology , leptin , diabetes mellitus , adipokine , insulin , obesity , chemistry , food science
We investigated the effects of raspberry consumption on diabetes‐related complications and heart disease in obese diabetic mice. Mice (4–5 wk old) were fed either AIN‐93G (control) or AIN‐93G supplemented with freeze‐dried raspberries (9.75%) (isocaloric) for 8 wk. At the end of the study, blood and heart tissues were collected and analyzed using standard analytical protocols. Raspberry intake, at dose equivalent to 208 g freeze dried raspberry/day for a 60‐kg human adult; protected against appetite loss, weight loss and cachexia observed in the control group. However, levels of lipid peroxidation, pro‐atherogenic molecules, and endotoxins in plasma were similar between groups. Plasma adipokine resistin, a hormone signaling molecule correlated with hyperinsulinemia/hyperglycemia, was higher in raspberry group (1777 vs 1165 ρg/mL, p < 0.05). Controversially, no differences were found in plasma insulin concentrations; whereas fasting glucose tended (p = 0.08) to be lower in the raspberry group (688 vs 759 mg/dL). This suggests that higher concentrations of plasma resistin in the raspberry group is correlated with higher body weight and is consistent with its delayed cachexia. Heart tissue disease biomarkers leptin, resistin, total cholesterol, triglycerides, and oxidized lipids were similar between experimental groups. However; plasminogen activator inhibitor‐1 (PAI‐1) tended to be lower in the raspberry compared to the control group (1124 vs 1234 ρg/mg protein) (p > 0.05). PAI‐1 has been linked to decreased oxidative stress and interleukin‐6 in blood. These findings demonstrate that raspberry consumption helps to decrease cachexia and may decrease cardiac fibrosis in diabetes at an advanced age. Future studies are needed to prove the clinical relevance of raspberry consumption. Support or Funding Information National Processed Raspberry Council, Grant # 3057‐6667