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Low intake of fruit and vegetables, body fatness and pro‐inflammatory/pro‐oxidant status are the major determinants of plasma carotenoids reduction in free‐living adults
Author(s) -
Manda Rodrigo Minoru,
Kano Hugo Tadashi,
Vilches Gabriel Nogueira,
Selingardi Roberta,
Abe Ligia Mayumi,
Correa Camila Renata,
Burini Roberto Carlos
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.689.6
Subject(s) - carotenoid , lycopene , lutein , food science , overweight , obesity , medicine , retinol , chemistry , vitamin
Previous data had shown that subjects involved in our ongoing epidemiological study “Move For Health” have a monotonous ingested (low variety) food in a poor quality (low HEI score) diet characterized by high sugar and oil servings and inadequacy of whole grains, fruits and vegetables. Fruits and vegetables are considered the main natural sources of carotenoids, detected in the plasma. The aim of the study was to investigate the relationship of food intake with major circulating carotenoids, and related components either plasma lipids and/or pro‐inflammatory, pro‐oxidative markers, in female adult subjects enrolled in a lifestyle modifications Program (LSMP). The cross‐sectional analysis involved retrospective data of demographic, anthropometric, dietary (24h food intake recall), plasma general chemistry (lipids), oxidative inflammatory (hs‐CRP, γ‐GT, HOMA‐IR, MDA, uric acid) markers and lipo‐soluble vitamins (retinol, α‐tocopherol, β‐carotene and others carotenoids (β‐criptoxanthin, lutein and lycopene). Mean (±SD) were compared by Student t‐test for age, and continued values among variables were correlated by the Spearman test for p=0.05. Overweight (29.6±5.74 kg/m 2 ) high body fat (37.0±8.79%) and abdominal fat (WC=96.8±13.8cm) women, presenting high plasma total cholesterol (tchol=201±30.1mg/dL) and triglycerides (TG=154±49mg/dL) levels along with high HOMA‐IR (3.38±3.05), presented circulating vitamins inside their normal range. However, the ingested sources of these vitamins were considered below the recommended amounts. All but lycopene carotenoids plasma levels were negatively related to BMI, %fat and WC as well as plasma TG (including lycopene), tchol and LDL‐chol (only β‐carotene). The inflammatory/oxidative/insulin resistance‐related markers showed reverse relationship with plasma carotenoids, more complete with γ‐GT and MDA (for β‐carotene, β‐criptoxanthin and lutein). The best relationship (β‐carotene, β‐criptoxanthin and lutein) was found with the food intake of fibers and vegetables. Thus, free‐living adults presenting lower intake of carotenoids might affect their plasma levels, which is aggravated by their hyperadiposity pro‐inflammatory status. Nutritional intervention with fruits and vegetables adequacy would reverse or attenuate the situation. Support or Funding Information Supported by CAPES and CNPq