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An oral iron compound that decreases colon cancer cell growth
Author(s) -
Scheers Nathalie M,
Pereira Dora A,
Powell Jonathan J
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.688.3
Subject(s) - colorectal cancer , cancer , cancer research , carcinogenesis , caco 2 , cancer cell , cell growth , cell , biology , chemistry , medicine , biochemistry
In several murine studies, supplemental or fortificant iron, that is used for human consumption, has been shown to promote colon tumorigenesis in mice. How this translates to humans is not clear but deserves careful investigation. Here, we studied how different potential oral iron compounds affected the growth of human colon cancer cells. The growth rate of intestinal adeno‐carcinoma cells (Caco‐2 and HT29) was monitored until confluence. In addition, the expression of 87 different cancer‐related proteins were investigated by antibody arrays. Surprisingly, we identified an iron compound that actually limited the growth rate of human cancer cells and the array data indicate that changes in cell cycle control may be implicated. This compound could play a role in colorectal cancer prevention, perhaps even as a food fortificant, and merits further investigation. Support or Funding Information The Swedish Research Council Formas (grant no. 222‐2014‐417)