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Obesity Risks Associated with Low‐ and High Birth Weight and They Varied by Population Obesity Prevalence: A systematic Review and Meta‐analysis
Author(s) -
Song Taixia,
Wang Youfa,
Huang Wenjie,
Lu Lu,
Zhao Yong,
Sharma Manoj,
Zhang Yong
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.667.3
Subject(s) - obesity , medicine , overweight , birth weight , meta analysis , population , relative risk , obstetrics , low birth weight , demography , confidence interval , pregnancy , environmental health , biology , sociology , genetics
Objectives This systematic review examined obesity susceptibility in populations with different obesity prevalence, assessed obesity risk associated with low‐ and high birth weight( ie, tested “fetal origins” of obesity). Nutrition affects birth weight and obesity, while during prenatal stage it may modify metabolisms in that fetus can adapt to maternal nutritional status. Therefore, individual with different birth weight might have different susceptibility to obesity and its susceptibility might change in different nutrition conditions. METHODS Pubmed and Embase databases were searched for relevant studies. Relative risk (RR) of overweight/obesity (OW/OB) compared with normal birth weight was analyzed by description and meta‐analysis. During meta‐regression, the OW/OB prevalence of samples was introduced to analyzing of association of birth weight and risk of OW/OB. RESULTS Forty‐one studies met inclusion criteria. The pooled RR of OW/OB for low birth weight (LBW) was 0.80 (95%CI, 0.75–0.84, I 2 =73.0%), and 1.52 (95%CI, 1.45–1.60, I 2 =87.2%) for high birth weight (HBW). Meta‐regression showed that RR of OW/OB for LBW was positively associated with OW/OB prevalence ( β =0.496, SE=0.244, p =0.046), and, for HBW, it was negatively associated with OW/OB prevalence ( β =−0.722, SE=0.268, p =0.009). CONCLUSIONS LBW was associated with lower risk of subsequent OW/OB; the relation was stronger in countries with high obesity prevalence. HBW incases risk of subsequent OW/OB, and the relations was weaker in countries with high obesity prevalence. The findings support “fetal origins” hypothesis in obesity development. Support or Funding Information National Natural Science Foundation of China (No. 30901189) and NIH U54 center grant, HD070725