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Caspase Activity in Early Stage Regeneration of A. viride Regulated by the Wnt/β‐Catenin Signaling Pathway
Author(s) -
Fok Sheridan
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.647.4
Subject(s) - wnt signaling pathway , regeneration (biology) , microbiology and biotechnology , blastema , biology , catenin , signal transduction
It has been widely known that invertebrates posses extraordinary regenerative ability to repair their lost tissues or organs. Aelosoma viride , a fresh water annelid, can complete anterior regeneration within 5 days post amputation. In addition, its relatively small body size (2mm in length) and transparent color can be easily manipulated for regeneration study. Regeneration processes of A. viride are similar to other model organisms, including wound healing, blastema formation, and tissue remodeling. Apoptotic caspase has been known to be required during early stage regeneration. A previous study done by RNA interference showed that A.viride could not complete its anterior regeneration when Avi‐caspase‐3/7 was knocked down. Recent studies have demonstrated that wnt/β‐Catenin signaling pathway can promote apoptosis through a caspase‐dependent pathway. Also, our previous studies have showed that gene expression of both Avi‐wnt‐4 and β‐Catenin elevated in the anterior region during early stage of regeneration. Thus, our future studies will try to realize whether or not caspase activity in early stage regeneration is regulated by the wnt/β‐Catenin signaling pathway in A. viride .