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A Lipid Fraction from Catfish (Arius bilineatus, Val.) Potently Inhibits Collagen‐induced Aggregation in Vitro
Author(s) -
PaceAsciak Cecil,
AlHassan Jassim M.,
Afzal Mohammad,
Paul Bincy Maniyalil,
Oommen Sosamma,
Liu Yuan Fang
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.612.5
Subject(s) - catfish , in vitro , chemistry , ic50 , pharmacology , biochemistry , medicine , biology , fishery , fish <actinopterygii>
The catfish (Arius bilineatus, Val.) secretes a gelatinous substance from their skin upon threat or injury. The gel is composed of lipids and proteins. Preparations from the skin have previously been shown to possess a number of biochemical and pharmacological activities including blood clotting, healing of non‐healing diabetic foot ulcers and relief from neuropathic pain in man. The crude lipid preparation was subjected to chromatography on silica gel. The chloroform fraction was most potent in inhibiting collagen‐induced aggregation of washed human platelets in the presence of added calcium (IC50 = 5 ug/250e6 cells/0.5 ml). Purification of the active compounds is being pursued. Support or Funding Information Supported by a grant from Kuwait Foundation for the Advancement of Science No. KFAS 201320701A‐D, and Kuwait University Research Grant No. SL03/14.