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The Hypoglycaemic Potential of Antioxidant‐Rich Food Extracts
Author(s) -
Chepulis Lynne
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.428.6
Subject(s) - postprandial , antioxidant , food science , prediabetes , meal , glycemic , medicine , glycemic index , sugar , blood sugar , carbohydrate , functional food , diabetes mellitus , area under the curve , type 2 diabetes , chemistry , biochemistry , pharmacology , endocrinology
Background/Aims Prediabetes and Type 2 diabetes are highly prevalent in the USA as well as Western countries, and both conditions are associated with impaired glucose control. Research suggests that low GI diets and reduced HbA1c values can be one means by which disease progression can be slowed, and antioxidants have been identified as having the ability to regulate plasma glucose levels. The aim of this study is to assess the effects of specific high‐antioxidant food extracts on postprandial glucose responses to sugar (glucose) and a basic carbohydrate meal. Methods Ten healthy individuals were recruited into a randomized, single‐blinded study. Participants were asked to consume various high‐antioxidant food extracts that were matched for total antioxidant content 10 mins prior to 50g of available carbohydrate from either glucose or white bread (with ham) after an overnight fast. Blood glucose levels were measured using capillary sampling every 15 mins for two hours, and the incremental area under the glucose curve (IAUC) measured. The IAUC values for the test food extracts were compared to the glucose‐only and bread/ham‐only controls. Results Amla berry‐, Grape seed‐ Rooibos tea‐ and Green tea‐ extracts as well as Propolis tincture were all strong glycemic modulators, significantly decreasing the IAUC by 25–39% compared to the glucose‐only or bread‐only controls (all p < 0.05). All extracts were well tolerated, and no more than one gram of extract was required to achieve the aforementioned results. Conclusions Antioxidant‐rich food extracts are able to reduce the postprandial response of glucose and white bread with ham; thus they may offer a potential means by which glycemic control could be managed in individuals who have impaired glucose control. Support or Funding Information This study was funded by in part by Manuka Health New Zealand Ltd, and in part by Waiairki Institute of Technology, New Zealand