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Dietary Enrichment with Blueberry and/or Probiotics Does Not Alter Blood Pressure Variability Compared to Control Diet in Hypertensive Rats
Author(s) -
Blanton Cynthia,
He Zhengcheng,
GottschallPass Katherine T.,
Sweeney Marva I.
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.416.7
Subject(s) - blood pressure , coefficient of variation , diastole , analysis of variance , zoology , post hoc analysis , medicine , endocrinology , biology , food science , chemistry , chromatography
Variability in blood pressure (BP) is a risk factor for cardiovascular events independent of mean BP. Recently we showed that feeding polyphenol‐rich wild blueberries (BB) or probiotics (PRO) to hypertensive rats reduced the characteristic rise in BP over time. Here we report the effect of these diets on BP variability. Groups (n=8 each) of male spontaneously hypertensive rats were fed one of four AIN93G‐based diets for 8 weeks: Control; 3% freeze‐dried wild BB; 1% probiotic bacteria (PRO); or 3% BB + 1% PRO. BP was measured biweekly by the tail‐cuff method. The standard deviation (SD) and coefficient of variation (CV) of diastolic and systolic BP were compared across groups using 2‐way ANOVA with repeated measures. Results Separate diet enrichment with BB or PRO did not have a significant effect on BP variability (p>0.10). However, the interaction of enrichment with BB and PRO had a significant effect on diastolic BP SD (p=0.016) and CV (p=0.007), with post‐hoc comparisons showing lower variability in the BB+PRO vs. BB group (p<0.05). BP variability was not different from control for any enriched diet. Conclusion Diet enrichment with separate or combined BB and PRO does not affect BP variability compared to control diet in hypertensive rats. Adding PRO to BB‐enriched diets might alter BP variability. Support or Funding Information Wild Blueberry Association of North America