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Plasma Trans Palmitoleic Acid and Cardiometabolic Risk factors in Youth with Type 1 Diabetes: SEARCH Nutrition Ancillary Study
Author(s) -
The Natalie S.,
King Irena B.,
Crandell Jamie L.,
Couch Sarah,
Tzeel Benjamin,
Liese Angela D.,
Dabelea Dana,
MayerDavis Elizabeth
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.290.4
Subject(s) - medicine , palmitoleic acid , diabetes mellitus , national health and nutrition examination survey , waist , body mass index , endocrinology , type 2 diabetes , blood pressure , type 1 diabetes , population , fatty acid , linoleic acid , environmental health , biology , biochemistry
The identification of modifiable risk factors associated with cardiometabolic traits is critical for improving health outcomes in persons with type 1 diabetes (T1D). The adverse effects of trans fatty acids from industrial hydrogenation of oils on health outcomes are well‐documented, but less is known about the health effects of trans fatty acids produced from biohydrogenation by bacteria in ruminant gut, such as trans palmitoleic acid (TPA; 16:1n‐7t). We examined the association between plasma TPA and cardiometabolic outcomes using data from the SEARCH for Diabetes in Youth Study, an ongoing multi‐center observational cohort study of youth with diabetes diagnosed at < 20 years of age. Participants included those with physician‐diagnosed T1D and positive diabetes autoantibody (glutamic acid decarboxylase‐65 or insulinoma‐associated‐2 autoantibodies) at enrollment (n=826; diabetes duration mean=10.0 mo). Cross‐sectional, linear regression models adjusted for confounders (gender, age, diabetes duration, human leukocyte antigen risk, insulin regimen, insulin dose, race and ethnicity, study site, and maximum parental education) identified a positive association of plasma TPA with low‐density lipoprotein cholesterol (β=2.1; p=0.02), total cholesterol (β=3.1; p=0.003), and diastolic blood pressure (β=0.9; p=0.003), as well as a positive association with high‐density lipoprotein (HDL) cholesterol (β=0.8; p=0.002). No association was observed between TPA with HbA1C, insulin sensitivity, triglycerides, body mass index z‐score, systolic blood pressure, and waist circumference. An adjusted repeated measures model using a smaller sample of participants who had data at baseline and at a follow‐up visit (either 12‐ or 24‐months after baseline visit; n=379) yielded identical results. Findings suggest a differential and complex relationship of TPA on various cardiometabolic traits in youth with T1D. Additional research is needed to determine long‐term effects of plasma TPA on cardiometabolic health in youth with T1D and identify the mechanisms by which TPA may impact these traits. Support or Funding Information 2R01DK077949‐05