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The Phase of Fat: Mechanisms and Physiology of Lipid Synthesis and Storage
Author(s) -
Farese Robert V.,
Walther Tobias
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.243.3
Subject(s) - organelle , lipid droplet , membrane lipids , cytosol , chemistry , microbiology and biotechnology , lipidomics , membrane , biochemistry , biophysics , biology , enzyme
Lipids play a crucial and tightly regulated role in cells as the major component of membranes. Neutral lipids, such as triglycerides, are also crucial for both cellular and physiological energy homeostasis. Membrane precursor lipids and energy storage lipids are stored as neutral lipids in cytosolic lipid droplet organelles. We are studying the molecular processes that govern the synthesis of energy storage lipids as well as their storage in and mobilization from lipid droplets. Studies on genetic factors controlling lipid droplet growth and utilization will be presented, as will relevant studies of the physiology of lipid storage.