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H 2 S‐RELEASING ASPIRIN EXERTS PROTECTIVE EFFECT IN ESOPHAGEAL AND GASTRIC MUCOSAL STRESS‐ASSOCIATED INJURY
Author(s) -
Zayachkivska Oksana,
Bula Nazar,
Pavlovsky Yaroslav,
Gavriluk Elena,
Wallace John
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1271.1
Subject(s) - aspirin , medicine , ulcer index , gastric mucosa , gastroenterology , pharmacology , stomach
Aspirin is one of the widely prescribed antiplatelet and anti‐inflammatory drugs and last data expanded its role into complex biological processes such as cancerogenesis, tissue repair, and aging, despite that well know its effects for peptic ulcer or gastrointestinal (GI) bleeding which can develop even in an achlorhydric environment. Recent extensive research of activities of hydrogen sulfide (H 2 S) has proven that the addition of H 2 S‐releasing moiety to the classical non‐steroidal anti‐inflammatory drugs (NSAID) results with GI cytoprotective activity. The objective of this study was to evaluate the effects of novel NSAID‐H 2 S compound ‐ ATB 340 (Antibe Therapeutics Inc), hydrogen sulfide‐releasing derivative of aspirin (H 2 S‐aspirin) in esophageal and gastric mucosal defence in a rat model of stress injury. Methods Rats were treated with vehicle (control), classical aspirin (10 mg/kg), ATB‐340 (17,5 mg/kg) with or without being subjected to injury according to the University Ethical Committee Approval (21.05.2014, N o 5). The damage of the esophageal mucosa (EM) and gastric mucosa (GM) was estimated via scoring lesion index by histomorphological analysis. Serological levels of VCAM‐1, IL‐6 by ELISA Kits (Cedarlane, Canada) were evaluated. Results Treatment by ATB‐340 resulted in protective effect and lower grade of EM & GM lesions in twice by damage index. The basal levels of VCAM‐1, IL‐6 from aspirin‐treated rats and suspected to stress‐injury were higher that of control animal. Pre‐treatment by ATB‐340 exerted an anti‐inflammatory effect by decreasing VCAM‐1 and IL‐6 vs classical aspirin. Conclusion These results indicate that inhibiting inflammation and improving endothelial functions modulate protective effect of H2S‐aspirin.