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Influence of electrical and natural stimulation of pharyngeal/laryngeal sensory afferents on the swallow motor pattern
Author(s) -
King Suzanne,
Bolser Donald C.,
Rose Melanie J.,
Poliacek Ivan,
Shen Tabitha Y.,
Musselwhite M. Nicholas,
Pitts Teresa
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1261.3
Subject(s) - electromyography , stimulus (psychology) , superior laryngeal nerve , medicine , stimulation , sensory system , swallowing , anatomy , anesthesia , phonation , larynx , audiology , neuroscience , physical medicine and rehabilitation , surgery , biology , psychology , psychotherapist
Electrical stimulation of the superior laryngeal nerve (ES‐SLN) is a method that is a mainstay to study swallow. Although its efficiency in evoking a swallow motor response has been well proven, it is a deterministic stimulus that is unlike natural stimulation (mechanical/chemical) of the diverse afferent beds lying in aerodigestive tract. We hypothesized that swallowing muscle activity induced by injection of water into the oropharynx would contrast those produced by ES‐SLN. Swallow was evoked in anesthetized spontaneously breathing cats via injection of a 3cc bolus of water, unilateral ES‐SLN (5 and 20Hz), or a combination of 5Hz ES‐SLN with water. Electromyography (EMG) activity (duration, amplitude) was measured concurrently in thyrohyoid, thyropharyngeus (ThPh), mylohyoid, geniohyoid, cricopharyngeus, parasternal, and posterior cricoarytenoid muscles. Significant stimulus‐related effects were observed in ThPh when a stimulus was presented individually, as indicated by increases in mean amplitude with 5Hz ES‐SLN compared to water alone. No differences were found between ES‐SLN (either frequency) compared to a combination of ES‐SLN with water. Additionally, an inverse relationship was apparent between the frequency of the ES‐SLN and the amplitude of ThPh activity. Current results suggest: a) stimulus modality influences the motor pattern of the pharyngeal phase of swallow in an anesthetized animal model and b) frequency dependence of afferent feedback on the spatiotemporal features of some, but not all, swallow‐related motor outputs. Supported by HL 111215, HL 103415, P30‐GM103507. Support or Funding Information Supported by HL 111215, HL 103415, P30‐GM103507.