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Perinatal taurine depletion depresses the renal tubular effect of estrogen in adult female rats independent of high sugar intake
Author(s) -
Roysommuti Sanya,
Lerdweeraphon Wichaporn,
Wyss James Michael
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1213.2
Subject(s) - endocrinology , medicine , renal function , taurine , excretion , saline , tamoxifen , estrogen , kidney , weaning , chemistry , amino acid , breast cancer , biochemistry , cancer
Perinatal taurine exposure affects adult renal function. This study tests the hypothesis that the adverse effect of perinatal taurine depletion on renal excretory function in adult female rats is modified by estrogen status. Female Sprague‐Dawley rats were fed normal rat chow and given water alone (C) or water containing 3% beta‐alanine (taurine depletion, TD) from conception until weaning. After weaning, the rats received normal rat chow and tap water with (CG, TDG) or without (CW, TDW) 5 % glucose. At 7–8 weeks of age, renal function at rest and after acute saline load (5% body weight) was tested in conscious, restrained female rats treated with or without estrogen receptor blockade (tamoxifen; 10 mg/kg/day in drinking water for a week). Body, heart, and kidney weights were not significantly different among the eight groups. Compared to control, TD did not affect mean arterial pressure (MAP) or heart rate. Tamoxifen treatment significantly increased only resting MAP in TDG compared to TDW and heart rate at rest and after saline load in CG compared to CW groups. Effective renal blood flow, renal vascular resistance, glomerular filtration rate, and sodium and water excretion were not significantly different among the corresponding (tamoxifen treated and untreated) groups. Fractional sodium and water excretion were markedly and significantly depressed after a saline load in CG, TDW, and TDG compared to CW groups, but these differences were eliminated by tamoxifen treatment. These data indicate that in adult female rats, the adverse effects of perinatal taurine depletion on the renal tubule is modified by estrogen status, independent of high sugar intake. Support or Funding Information Khon Kaen University