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Enhancing Molecular Targets in Cancer through the use of Very Low Level Radiation
Author(s) -
Branly Rolando,
Oseni Saheed O,
KumiDiaka James,
Tulp Orien
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1194.10
Subject(s) - lncap , radiation , apoptosis , cancer , cancer research , cancer cell , computational biology , monte carlo method , computer science , in vitro , radiation therapy , physics , chemistry , biophysics , biology , medicine , biochemistry , optics , mathematics , statistics
Some recent studies show increased levels of apoptosis in cancer cell cultures utilized for phytonutrient effect studies when a low dose of X‐rays is initially given. We consider some of the effects of electromagnetic radiation in the production of intra‐cellular acoustical waves and the implications for altered probabilities of Biochemical Pathways. Monte Carlo simulation methods are employed with initial coarse grid models based on in vitro studies using LNCaP and PC3 cancer cell lines in combination therapy studies with X‐rays. Very Low Dose Radiation with X‐rays appears to enhance apoptosis mechanisms in the laboratory. The models presented serve as useful tools for temporal effect studies. Support or Funding Information We are thankful and acknowledge institutional support