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Anti‐invasive activity of capsaicin and natural capsaicin‐like compounds in human NSCLC
Author(s) -
Nolan Nicholas A,
Hurley John D,
Williams Cathryn,
Rollyson William D,
Brown Kathleen C,
Akers Austin T,
Eskew Matthew N,
Perry Haley E,
Egleton Richard D,
Dasgupta Piyali
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1193.8
Subject(s) - capsaicin , metastasis , medicine , lung cancer , cancer , cancer research , oncology , receptor
Non small lung cancer (NSCLC) accounts of 80% of all lung cancer cases. About 30–40% of NSCLC patients present with metastatic disease at the time of their diagnosis. The average survival time of such NSCLC patients is about 7 months. The invasion of neoplastic cells to the surrounding stroma is a vital step of cancer metastasis. Recent studies have shown that nutritional compounds (by themselves or in combination with standard chemotherapy) can suppress metastasis of several human cancers. Capsaicin is the spicy ingredient of chili peppers. Recent studies have shown that capsaicin inhibits the invasion and metastasis of several types of human cancers including melanoma, prostate cancer and cholangiosarcoma. We investigated the anti‐invasive properties of capsaicin and two capsaicin‐like compounds, capsiate and capsiconiate, found in select variety of chili peppers on NSCLC. We measured the anti‐invasive activity of these compounds by the Boyden chamber assay. We found that capsaicin and capsiate displayed equivalent anti‐invasive activity in NSCLC cells. In contrast, capsiconiate did not suppress the invasion of NSCLC cells. The anti‐invasive activity of capsaicin, capsiate and capsiconiate in human NSCLC was found to be independent of their growth‐inhibitory activity. Currently, we are testing the anti‐metastatic activity of capsaicin in syngenic mouse models of metastasis. The results of our studies may foster the hope of nutrition‐based interventions in NSCLC metastasis. Support or Funding Information Funding for our study was supported by the an NIH R15‐AREA Grant (1R15HL113681‐01A1), AICR Investigator Grant, and a NASA Undergraduate Fellowship to NAN