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Active anti‐methamphetamine vaccination attenuates the effects of methamphetamine
Author(s) -
Taffe Michael A,
Nguyen Jacques D,
Bremer Paul T,
Vandewater Sophia A,
Creehan Kevin M,
Janda Kim D
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1184.5
Subject(s) - methamphetamine , keyhole limpet hemocyanin , medicine , nasal administration , vaccination , stimulant , addiction , pharmacology , self administration , immunology , antibody , psychiatry
Successful treatment remains elusive for methamphetamine (MA) addiction, which remains a serious public health concern. Immunopharmacotherapy has been shown to attenuate many effects of MA in rodent models. This study further investigated the efficacy of an anti‐MA vaccine in rats with locomotor and self‐administration assays. Male and female rats were vaccinated with either a control keyhole‐limpet hemocyanin vaccine (KLH) or a candidate anti‐MA vaccine (MH6‐KLH conjugate). MH6‐KLH vaccination blocked the homecage locomotor stimulant effects of MA (i.p.) in a dose dependent manner in female rats. The MH6‐KLH vaccine also interfered with a suppression of wheel running activity observed 30 min after vapor inhalation of MA in male rats. The MH6‐KLH vaccine also reduced the reinforcing efficacy of MA, but not alpha‐PVP, in intravenous self‐administration under a Progressive Ratio dose substitution procedure in male rats. This study further confirms the efficacy of the MH6‐KLH candidate vaccine and more generally that active immunopharmacotherapy can attenuate the effects of MA. Support or Funding Information NIH Grant R01 DA024705