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Elasticity and Vascular Endothelial Function in Patients with Aortic Valve Insufficiency
Author(s) -
Silveira João Vicente,
Katayama Keyla Yukari,
Sangaleti Carine Teles,
Ferreira Janaina,
Hong Valeria Costa,
Lopes Heno Ferreira,
ConsolimColombo Fernanda Marciano
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1177.2
Subject(s) - medicine , cardiology , asymptomatic , volume overload , blood pressure , heart failure , hemodynamics , regurgitation (circulation) , aortic valve
Backgroud Aortic insufficiency (regurgitation) is a common valve disease in young and middle‐aged individuals, which requires from the cardiovascular system a continuous volume overload. Patients can remain asymptomatic for many years and subsequently they can present symptoms of congestive heart failure. The remodeling of the great vessels has been observed in patients with severe regurgitation. However, little is known about the changes in the elasticity of small arteries and endothelial function in a moderate condition, without clinical symptoms. Aim Our goal was to assess small artery elasticity and endothelial function by peripheral arterial tonometry. The hemodynamic profile was characterized by the continuously and noninvasively analyses of the blood pressure curves. Methods We evaluated 41 individuals of both gender, aged 18–55 years divided into two groups: control (n = 23 healthy) and aortic regurgitation (n = 18, classified as mild to moderate through Doppler echocardiography criteria, and asymptomatic). For the acquisition and analysis of hemodynamic variables: systolic blood pressure (SBP), diastolic (DBP), heart rate (HR), end‐systolic volume (ESV), cardiac output (CO) and total peripheral resistance (TPR), the monitor Finometer® and the BeatScope software was used. The vascular elasticity and endothelial function were assessed by the EndoPAT®. Statistical analysis was performed using Student's t test, unpaired, with p <0.05, the values are presented in mean ± SEM. Results Individuals with aortic regurgitation (48.5 ± 3.2 years; BMI 27.8 ± 1.4 kg/m 2 ) compared to the control group (n = 23, 41.7 ± 1.8 years; BMI 26 4 ± 0.7 kg/m 2 ) had the follows hemodynamic changes: increased SBP (138.6 ± 3.7 vs 126.7 ± 2.8 mmHg) ESV (151.7 ± 13.5 vs 83.9 ± 3, 0 ml) and CO (10.6 ± 1.0 vs 5.4 ± 0.2 l/min); and decreased DBP (64.7 ± 2.6 vs 75.3 ± 1.8 mmHg) and TPR (0.6 ± 0.1 vs 1.1 ± 0.1 UPR). Endothelial function was not different between groups. However, there was a significant increase in the elasticity of small arteries in the aortic regurgitation group in absolute values (20.2 ± 5.0 vs 5.7 ± 3.9%) and also for normalized values according to a HR of 75 bpm (16.9 ± 4,5 vs −2.5±3.9%). Conclusion Young adults with asymptomatic aortic regurgitation had a higher elasticity of the small arteries and a preserved endothelial function.