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The Effect of Moringa Oleífera Leaves in Anthropometric and Biochemical Parameters in Obese Type 2 Diabetes Mellitus Subjects
Author(s) -
DominguezRodriguez Maribel,
ValenzuelaRubio Nancy Guadalupe,
OchoaAcosta Dora Alicia,
FierrosValdez Jesus Antonio,
CastroSanchez Francisco Humberto,
VergaraJimenez Marcela
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1176.21
Subject(s) - moringa , medicine , crossover study , anthropometry , diabetes mellitus , placebo , type 2 diabetes , obesity , type 2 diabetes mellitus , endocrinology , traditional medicine , alternative medicine , pathology
Obesity is associated with the development of diabetes. Diabetes is one of the mayor public health problems worldwide. Several studies have demonstrated the hypoglycemic and hypolipidemic effects of Moringa oleífera leaves. The objective of this study was to evaluate the effect of Moringa oleífera leaves on anthropometric and biochemical parameters in obese‐type 2 diabetic subjects from Mexico. A crossover double‐blind design was carried out through 22w (10w for Stage 1, 2w for a washout period and 10w for Stage 2). We recruited 24 obese type 2 diabetics using metformin (17 woman and 7 men, 20–60y). All subjects were randomly assigned into 2 groups (AB or BA). Letter A represents placebo and B Moringa Oleifera leaves. During the study all subjects received moderate carbohydrate diet (Carbohydrates 40%, Protein 30% and fat 30%) and they were advised to maintain their usual level of physical activity. 4 blood draw points were collected (at the beginning and ending of each stage). Only 3 subjects finished the whole crossover study. Body weight and Insulin were reduced in A (p<0.05). BMI was significantly reduced by the end of the study. Although the differences between biochemical parameters were not statistically significant, c‐LDL and HbA1c showed a trend to be reduced in B. blood pressure was lower in B. c‐HDL increased in both groups. Fasting glucose concentrations were reduced in A and B. Our results suggest that Moringa oleifera leaves improves parameters associated with obese‐type 2 Diabetics and therefore it could be used as an alternative treatment to control the diabetic conditions of obese adults.