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The Effects Of Soluble Dietary Fiber On Blood Pressure: A Systematic Review And Meta Analysis Of Randomized Controlled Trials
Author(s) -
Jovanovski Elena,
Khan Kashif,
Sievenpiper John,
Ho Thanh,
Zurbau Andreea,
AuYoung Rodney,
Mejia Sonia Blanco,
Vuksan Vladimir
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1176.12
Subject(s) - medicine , meta analysis , randomized controlled trial , blood pressure , relative risk , publication bias , study heterogeneity , confidence interval
Objective Epidemiological evidence suggests an inverse relationship between soluble fiber intake and blood pressure, while evidence from randomized controlled trials remains largely controversial and poorly characterized. The present study aim is to conduct a systematic review and a meta‐analysis of randomly controlled trials to assess the effects of soluble fiber intake on blood pressure. Study Design Medline, EMBASE, CINAHL and Cochrane Central Register of Controlled Trials, through to January 2015 were searched. Randomized, controlled, clinical trials that were ≥30 days in duration testing soluble fiber supplementation against an adequate comparator were included. Two independent reviewers extracted the data and assessed study quality and risk of bias. Data were pooled using the generic inverse variance method with random effects model and were expressed as mean differences (MD) with 95% confidence intervals (CI). Study heterogeneity was estimated using Cochran Q‐statistic and quantified I 2 statistic. Studies were also assessed for their quality using the Heyland Methodological Quality Score and for risk of bias using Cochrane's risk of bias tool. Results Fourteen studies (n=1112 participants) were included for analysis. Soluble fiber had no effect on systolic (MD=1.00 mmHg [95% CI 2.46 to 0.46]) or diastolic (MD=L0.23 mmHg [95% CI 1.17, 0.71]) blood pressures. Substantial and moderate unexplained heterogeneity were present for the systolic (I 2 =63%, P=0.18) and diastolic (I 2 =40%, P=0.63) blood pressure analyses. Conclusion Pooled analyses show that dietary supplementation of soluble fiber from all sources is not associated with systolic or diastolic blood pressure reduction. More studies will need to be included in future meta analyses to better understand the potential blood pressure reducing effects of soluble fiber, especially in patients with hypertension, and to delineate potential benefits of highly viscous soluble fibers. Support or Funding Information Supported by Internal research funding.