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Antioxidant and anti‐inflammatory activity of phloroglucinol from seaweeds
Author(s) -
Kim JinSun,
Lee JeHyuk
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1174.12
Subject(s) - phloroglucinol , antioxidant , chemistry , dpph , nitric oxide , abts , anti inflammatory , biochemistry , nitric oxide synthase , food science , pharmacology , organic chemistry , biology
Seaweeds are used in several fields as well as foods due to the high nutritional value in carbohydrates, proteins, vitamins, minerals. Phlorotannins are abundant compound in Ecklonia cava and Sargassum sp. and have reported to have anticancer, anti‐hyperlipemia, antioxidant, anti‐diabetes, and antihypertension. Phloroglucinol, one of the phlorotannins, was investigated to have antioxidant and anti‐inflammatory activity in this study. Phloroglucinol had approximately 67.9 and 94.8% free radical scavenging activity in DPPH and ABTS assay. Suppression of nitric oxide (NO) production from LPS‐stimulated macrophage cells was monitored for anti‐inflammatory activity. Phloroglucinol showed approximately 38 and 43% inhibition in 20 and 40 μM concentration, respectively. Expression of iNOS (Inducible Nitric Oxide Synthase), an enzyme for NO production, was suppressed to approximately 49.2% in 40 μM phloroglucinol. In addition, the transcription of COX‐2 (cyclooxygenase‐2) gene was controlled by phloroglucinol. Taken together, a phloroglucinol in seaweeds had antioxidant and anti‐inflammatory activity, and it is anticipated to give basic information to functional study of seaweeds.