Premium
Sex Differences in the Responses of Gut Microbiome to Long‐term Dietary Selenium Deprivation and Aging in Short Telomere Mice
Author(s) -
Lu HsinYi,
Wu Ryan T.Y.,
Cheng WenHsing
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1170.9
Subject(s) - firmicutes , biology , microbiome , bacteroidetes , physiology , selenium , feces , telomere , zoology , genetics , ecology , 16s ribosomal rna , bacteria , chemistry , organic chemistry , dna
How sex, dietary selenium (Se) and aging interact and affect mammalian gut microbiome is not known. Here, we sequenced bacterial 16S ribosomal RNA libraries prepared from feces of male and female Terc −/− short telomere mice at 18 and 24 months of age on a Se‐deficient or –adequate (0.15 ppm Se as sodium selenate) diet since weanling. Results from principle coordination analysis demonstrated that the taxonomic composition and the abundance of selective genus of gut microbiome and ratios of Firmicutes/Bacteroidetes changed by age and dietary Se deprivation, but not sex. In addition, the microbial alpha biodiversity was assessed by a nonparametric Shannon index that represents within‐subject variations at species level. While Shannon index was increased as a result of the dietary Se deprivation and aging in the males, such within‐subject variations by Se deprivation and aging were decreased in the females. Taken together, sex affects changes of gut microbiome by dietary Se deprivation and age in short telomere mice.