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Effect of Sex on the Selenotranscriptomic Changes by Long‐term Dietary Selenium Deprivation and Aging in Short Telomere Mice
Author(s) -
Cao Lei,
Wu Ryan T.Y.,
Cheng WenHsing
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1170.7
Subject(s) - selenoprotein , endocrinology , medicine , selenoprotein p , selenium , thioredoxin reductase , iodothyronine deiodinase , glutathione peroxidase , deiodinase , biology , selenium deficiency , dio2 , chemistry , hormone , thioredoxin , oxidative stress , triiodothyronine , superoxide dismutase , organic chemistry
Male Terc −/− short telomere mice on a diet deficient in selenium (Se) and during the aging process show selenotranscriptomic changes in a tissue‐ and selenoprotein‐specific manner. The objective of this study was to determine the effect of sex on selenotranscriptome in Se‐deficient and ‐adequate (0.15 ppm Se as sodium selenate) Terc −/− mice at 18 and 24 months of age (early and late stage aging). Various organs were collected and examined for mRNA expression of the 24 mouse selenoproteins by quantitative RT‐PCR analyses. In the heart, the mRNA expression of glutathione peroxidase‐1, selenoprotein H, selenoprotein W, and selenoprotein M were decreased by dietary Se deprivation in both male and female Terc −/− mice. In contrast, the age‐dependent selenotranscriptomic changes differed dramatically by sex. Compared to 18 months of age, the mRNA expression of selenoprotein T, selenophosphate synthetase‐2, thioredoxin glutathione reductase, and selenoprotein O were decreased and iodothyronine deiodinase‐2 were increased only in females, while selenoprotein H were decreased only in males at 24 months of age. The sex effect on the selenotranscriptomic changes in other organs will later be presented. In conclusion, there are sex differences in selenotranscriptomic changes under these dietary and aging conditions.