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High serum folate concentration increases the mortality risk in patients with stage 1–3 colorectal cancer: a follow‐up study
Author(s) -
Huang ShihChien,
Huang YiChia,
Chiang FengFan,
Wang HweiMing
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1168.7
Subject(s) - medicine , colorectal cancer , hazard ratio , confounding , gastroenterology , homocysteine , stage (stratigraphy) , proportional hazards model , cancer , oncology , confidence interval , paleontology , biology
Although the possible dual role of serum folate in the development and progression of colorectal cancer (CRC) has been investigated, the association of serum folate with the survival risk of CRC is not clear. The purpose of this study was to assess the association of serum folate concentration with the mortality of CRC in patients with stage 1–3 CRC after curative tumor resection. This was a follow‐up study. Serum folate and plasma homocysteine concentrations of 137 patients with stage 1–3 CRC after curative tumor resection were measured at baseline and during a median follow‐up time of 1215 days till death (overall mortality) occurred or to the end of the study. Baseline plasma homocysteine concentration had no effect on the mortality of CRC, while high baseline serum folate concentration significantly increased the mortality of CRC after no adjustment or adjustment of potential confounders (hazard ratio, 1.03, 95% CI, 1.01 – 1.06). High serum folate concentration seems to have an adverse effect on patients with stage 1–3 CRC after curative tumor resection. Support or Funding Information This study was supported by the Ministry of Science and Technology, Taiwan (NSC 101‐2320‐B‐040‐016‐MY3 and MOST 104‐2320‐B‐040‐009‐MY3 and 104‐2320‐B‐040‐009‐MY3).