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Impact of Exercise and Exercise + Weight Loss on Markers of Inflammation and Angiogenesis in Older Overweight and Obese African American Adults
Author(s) -
Olender Sarah,
TussingHumphreys Lisa,
Castellanos Karla,
Schiffer Linda,
Fitzgibbon Marian,
Hughes Susan,
Fantuzzi Giamila,
Braunschweig Carol
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1168.1
Subject(s) - overweight , medicine , angiogenesis , inflammation , anthropometry , obesity , weight loss , vascular endothelial growth factor , cancer , tumor necrosis factor alpha , endocrinology , vegf receptors
Markers of inflammation and angiogenesis are upregulated in sedentary obese adults with research suggesting that both processes can negatively influence the development of cancer. Conceivably, modulating inflammation and angiogenesis through weight loss (WL) and increased physical activity could prevent or slow the development of cancer. The aim of this ancillary study was to examine the impact of an 8‐week exercise (E) and E+WL intervention on markers of inflammation and angiogenesis in older overweight and obese AA adults enrolled in the NIH Fit & Strong! Plus trial. Fasting blood levels of the inflammatory biomarkers C‐reactive protein, interleukin‐6, and tumor necrosis factor‐α (TNF‐α) and the angiogenic markers vascular endothelial growth factor (VEGF) and osteopontin were assessed at baseline and post‐intervention. Anthropometric and survey data was also obtained. Generalized estimating equations controlling for age, baseline BMI, and gender were used to assess mean post‐intervention change in the biomarkers. 72 subjects were randomized to E+WL and 83 to the E only group . Subjects were predominately female (88%), with a mean age of 67 years old and baseline BMI of 33.8 kg/m 2 . Albeit modest, subjects in the E+WL group lost a greater % of their baseline body weight post‐intervention vs. the E only group (−1.8% vs. −0.2%; p < 0.001). There was no significant difference in the inflammatory or angiogenic markers between the groups post‐intervention. A significant decrease in TNF‐α was observed in the E group only. VEGF was significantly lower post‐intervention in both groups compared to baseline. Post‐intervention changes in markers of inflammation and angiogenesis were minimal in older overweight and obese AA adults following an 8 week E or E+WL intervention. Modest weight loss, short intervention duration, and relatively low intensity physical activities may have impeded our ability to observe significant changes in the majority of markers. The relevance of these interventions for cancer risk reduction deserves further study. Support or Funding Information American Cancer Society Illinois Division #261775; NIH NIA #R01AG039374