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Physiological function of short‐chain fatty acid receptor under ketogenic condition
Author(s) -
Kasubuchi Mayu,
Hasegawa Sae,
Ichimura Atsuhiko,
Kimura Ikuo
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1163.4
Subject(s) - butyrate , ketogenic diet , ketone bodies , receptor , propionate , short chain fatty acid , biology , endocrinology , energy homeostasis , ketosis , diabetes mellitus , medicine , chemistry , biochemistry , neuroscience , metabolism , fermentation , epilepsy
Short‐chain fatty acids (SCFAs) such as acetate, propionate, and butyrate are produced by bacterial fermentation of dietary fiber with gut microbiota and are utilized as a major energy source in the host's body. Recently, it was reported that the SCFAs play important roles not only as essential nutritional components but also as intracellular signaling factor to maintain metabolic homeostasis via SCFAs receptors which are G protein‐coupled receptor. Additionally, it has been shown that a SCFAs receptor could be also regulated by β‐hydroxybutyrate which bear a structural resemblance to butyrate. Hence, it became clear that ketone body is an endogenous ligand for SCFAs receptors and controls physiological function under ketogenic condition such as starved state and diabetes mellitus. Here, we focus on the physiological function of other SCFAs receptor under ketogenic condition. Through several pharmacological experiments in vitro and vivo, we found that other SCFAs receptor also plays pivotal role under ketogenic condition. Hence, these findings could account for the pathophysiological function of SCFAs receptors on diabetes and may represent an important avenue of research for drug development for the treatment of diabetic ketoacidosis.