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Effect of Weight Loss on Leptin, Insulin, HOMA, TG/HDL and CRP Levels in Overweight and Obese Subjects
Author(s) -
Zago Liliana,
Felipoff Ana Lía,
Weisstaub Adriana,
Dupraz Hernán,
Presner Natalia,
Perdomo Clara,
Río María Esther,
Maselli María C,
Ortiz Victoria,
Pandolfo Marcela,
Infantino Carlos González
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1159.4
Subject(s) - medicine , overweight , weight loss , insulin resistance , leptin , endocrinology , obesity , insulin , anthropometry
The objective of this study was to evaluate the effect of weight loss on metabolic markers, insulin resistance and inflammation. 59 women (20–73 years) were incorporated into a weight reduction program based on changes to healthy diets and physical activity just to avoid sedentary. Patients were evaluated at T0 and 3 months later (T3) by anthropometric and biochemical measurements. In this study we analyze variation of serum insulin (INS), leptin (LEP), HOMA ((Glucose × Insulin)/405), TG/HDL ratio, and ultrasensitive C‐reactive protein (CRPu), as a consequence of weight loss, expressed as percentage of weight loss relative to initial weight (WL%). The initial BMI was 31.6 ± 4.31 kg/m 2 (Overweight: 41%, Obesity I: 39%, II: 12%, III: 8%). At T3, the patients were divided according WL% into 4 groups: WL% 0–4%: 18 patients; WL% 4‐ <7%: 17 patients; WL% 7–15%: 15 patients. The 4th group corresponded to 9 patients who maintained or increased their weight. LEP was the parameter which suffered the biggest changes, decreasing significantly between T0 and T3 in the groups with WL% 4‐ <7% (16.2 ± 9.53 vs 10.4 ± 6.11; P = 0.0006) and with WL% 7–15% (14.1 ± 6.9 vs 12.10 ± 8.38; P = 0.0038) ng/ml. INS and HOMA values decreased significantly only in the group with WL% 7–15%: INS (8.4 ± 5.37 vs 6.2 ± 3.43; P = 0.0093) μU/ml and HOMA (2.1 ± 1.46 vs 1.4 ± 0.78; P = 0.0082). TG/HDL ratio and CRP showed no significant changes in all groups, although percentage of patients with CRP> 3 mg/L, compatible with high risk of coronary heart disease, decreased from 47% to 33% in the group with the highest WL%. The obtained results suggest that a weight loss higher than 7% is required to achieve favorable changes in the studied metabolic markers, even when a weight loss of 4‐<7% may produce a significant reduction in leptin levels. Support or Funding Information Supported by UBACyT 20720130100006BA