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American Major Dietary Patterns and Age‐related Cataract
Author(s) -
Chiu ChungJung,
Gensler Gary,
Taylor Allen
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1157.9
Subject(s) - confidence interval , odds ratio , medicine , logistic regression , multivariate analysis , ophthalmology , food science , biology
Objective We aimed to evaluate the associations between major American dietary patterns and risk for cortical and nuclear cataract. Methods Dietary consumption data of 37 food groups were collected by a 90‐item Block food frequency questionnaire administered at the baseline Age‐Related Eye Disease Study (AREDS). Using the AREDS System for Classifying Cataracts, 2007 eyes with pure nuclear lens opacity, 1281 eyes with pure cortical opacity, and 2491 eyes without lens opacity were identified from 7,575 eligible eyes. Associations between dietary patterns and pure lens opacities were examined by using the generalized estimating approach to logistic regression. Results Two major dietary patterns were identified by principle component analysis and named Oriental and Western patterns. The Oriental pattern was characterized by higher intake of vegetables, legumes, fruit, whole grains, tomatoes, and seafood. The Western pattern was characterized by higher intake of red meat, processed meat, high‐fat dairy products, French fries, refined grains, and eggs. We ranked our participants according to how closely their diets line up with the two patterns by calculating the two pattern scores for each participant. For all nuclear opacity (grade >2), the multivariate‐adjusted odds ratio (OR) comparing the highest to lowest tertile of the Western pattern score was 1.36 (95% confidence interval (CI): 1.06–1.76; P trend =0.03), and for mild nuclear opacity (grade <4 but >2) the OR was 1.45 (1.12–1.89; P trend =0.01). No other significant associations were noted. Conclusions Our data indicate that consuming a Western dietary pattern is significantly associated with increased odds of early nuclear opacity. Support or Funding Information Financial support for this project has been provided by the RO1EY021826 (C‐J.C.) from the National Institutes of Health, the United States Department of Agriculture under agreements, 1950‐5100‐060‐01A (C‐J.C., A.T.), and RO1EY013250 and RO1EY021212 (A.T.). Correspondence to Chung‐Jung Chiu, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, e‐mail: CJ.Chiu@tufts.edu