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Association of Total Antioxidant Capacity with Mortality of U.S. Adults in Follow‐up Study of NHANES 1988–1994 and 1999–2004
Author(s) -
Kim Kijoon,
Vance Terrence M.,
Chen MingHui,
Chun Ock K.
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1154.1
Subject(s) - medicine , quartile , demography , national health and nutrition examination survey , population , proportional hazards model , mortality rate , cause of death , disease , confidence interval , environmental health , sociology
Antioxidant rich diets have been shown to reduce risk of chronic disease and mortality. However, studies on the association of total antioxidant intake and mortality using representative sample of the US population are limited. The aim of this study was to assess the relationship between dietary total antioxidant capacity (TAC) and all‐cause and disease specific mortality among US adults in NHANES 1988–1994 and 1999–2004. A total of 23,589 US adults aged 30 years and older participated in this study. TAC was calculated from one‐day 24‐h diet recall data at baseline and all‐cause, cancer and cardiovascular disease (CVD) mortality was through December 31, 2011. During a mean follow‐up of 13 years, 7,157 deaths occurred. Age‐standardized mortality rates per 100,000 population by all‐cause, cancer and CVD were 2164, 461 and 650, respectively. Under cause‐specific Cox proportional hazards models for sample survey data, inverse associations and dose‐response relationship were observed between TAC and all‐cause mortality (highest quartile (Q4) vs. Q1 ref. HR 0.75; 95% CI 0.68–0.82), cancer mortality (Q4 vs. Q1 ref. HR 0.68; 95% CI 0.55–0.84) and CVD mortality (Q4 vs. Q1 ref. HR 0.83; 95% CI 0.69–0.99) after adjusting for age, gender and total energy intake. The inverse association and dose‐response relationship still remained between TAC and all‐cause mortality (Q4 vs. Q1 ref. HR 0.88; 95% CI 0.79–0.98) and CVD mortality (Q4 vs. Q1 ref. HR 0.78; 95% CI 0.63–0.96) when further adjusted for relevant covariates. These findings support that greater consumption of antioxidants was beneficial to reducing risk of death from all‐cause and CVD. Support or Funding Information This study was supported by Allen Foundation Research Grant.