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The Effect Of Maternal Supplementation With A Lipid‐Based Nutrient Supplement On Infant Micronutrient Intake In Guatemalan Women And Infants
Author(s) -
Haber Juliana A.,
Solomons Noel W.,
Hampel Daniela,
Orozco Mónica N.,
Allen Lindsay H.
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1150.3
Subject(s) - micronutrient , medicine , breast milk , breastfeeding , anthropometry , breast feeding , pediatrics , lactation , environmental health , pregnancy , biology , biochemistry , genetics , pathology
BACKGROUND According to the World Health Organization (WHO), infants should be exclusively breastfed for the first 6 months of life. Despite the high adherence to the WHO guidelines in Guatemala, there is a high prevalence of malnutrition during early life, which increases during the first 6 months of age. This suggests that breast milk quality may be suboptimal with regard to provision of micronutrients. Our objective was to evaluate whether maternal supplementation with a lipid based nutrient supplement (LNS) would increase infant micronutrient intake from breast milk. METHODS The randomly‐allocated, cross‐over design included 30 mother‐infant dyads 4–6 months postpartum in Quetzaltenango, Guatemala. In three 8‐hour milk collection visits the participating mother received a single bolus dose of 30 g LNS (B), 10 g of LNS divided over 3 time points (D), or no LNS (C). Mid‐feed milk samples were collected at each infant feed and total milk consumption measured. Maternal blood was collected at baseline, maternal dietary intake was assessed, and maternal and infant anthropometry was measured. The primary outcome was infant B‐complex vitamin intake from breast milk, estimated using micronutrient analyses and infant milk consumption. Analysis of variance and pair‐wise comparisons were used to examine the effect of dosing regimen. Clinicaltrials.gov (NCT02464111on). FINDINGS Of 26 dyads completing the study, results for 8 are included in this preliminary data analysis. On average, during 8 hours infants consumed more riboflavin when their mother received LNS (B or D), compared to C (9±6 μg, treatment p=0.012). B increased infant riboflavin intake by 28±21 μg, (p=0.005) whereas D increased intake by 19±14 μg (p=0.018). Neither B nor D increased infant pyridoxal (B 37±29 μg, D 44±36 μg, C 23±10 μg, p=0.328), niacin (B 41±31 μg D 37±30 μg, C 30±17 μg, p= 0.490) or thiamin (B 4±2 μg, D 6±6 μg, C 4±3 μg, p= 0.408) intake compared to no‐supplement. Compared to C, over 8 hours B provided an extra 6%, 0%, 14%, 1% of the Adequate Intake for infants under 6 months for riboflavin, thiamin, pyridoxal, and niacin, respectively, whereas D provided an extra 3%, 1%, 21%, 0%, respectively. INTERPRETATION Maternal supplementation with LNS as a bolus dose or divided dose increased infant riboflavin intake, with the bolus dose proving more efficacious at increasing infant riboflavin intake from milk. In this initial group of dyads, maternal supplementation with LNS did not significantly impact infant pyridoxal, niacin, or thiamin intake. Support or Funding Information UC Global Health Initiative, Blum Center for Developing Economies, UC Davis, USDA ARS Western Human Nutrition Research Center.