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Structured RNAs that Manipulate the Translation Machinery
Author(s) -
Kieft Jeff S
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.113.2
Subject(s) - internal ribosome entry site , translation (biology) , computational biology , ribosome , mechanism (biology) , translational regulation , rna , biology , computer science , genetics , messenger rna , physics , gene , quantum mechanics
Translation is a complex process that is subject to precise regulation throughout all of its phases, but the repertoire of mechanisms by which this regulation is achieved remains unknown. We are interested in understanding one particular class of regulation mechanism: how structured RNA elements embedded within mRNAs can alter or regulate translation through direct interaction with the ribosome. Such interactions can drive non‐canonical modes of translation initiation (e.g. cap‐independent or IRES‐driven translation), programmed ribosomal frameshifting, enhancement of the rate of translation, etc. Many of the most useful model systems for understanding how diverse structured RNAs can manipulate the ribosome come from viral RNAs, therefore these have been the focus of much of our research. We employ a combination of structural biology, biophysics, biochemistry, and virology. In this talk, I will present some of our latest findings and efforts to link the structure of a given RNA with its ability to manipulate the translation machinery. Support or Funding Information Howard Hughes Medical Institute early Career Scientist Award National Institutes of Health R01GM081346 & R01GM097333 Cancer League of Colorado