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New biomarkers in immune cells for inflammation‐related diseases
Author(s) -
Wang Hongyan,
Li Weiyun,
Xu Xiaoyan,
Han Lei,
Wei Bin
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1106.1
Subject(s) - inflammation , hepatocellular carcinoma , christian ministry , proinflammatory cytokine , medicine , immunology , immune system , fibrosis , biomarker , stat3 , cancer research , apoptosis , biology , political science , biochemistry , law
TLR‐triggered uncontrolled inflammation plays key role for the induction of inflammation‐associated HCC (hepatocellular carcinoma). We have recently identified that STK4 dampened TLR‐induced proinflammatory cytokine secretion but enhanced IFN‐beta production via binding to and phosphorylating IRAK1, leading to the degradation of IRAK1. Specific deletion of Stk4 in macrophages promoted chronic inflammation, liver fibrosis and HCC in murine models. Importantly, macrophages from human HCC patients reduced STK4 expression, which was inversely associated with the levels of IRAK1, IL‐6 and phospho‐p65 or phospho‐STAT3. Treatment of the IRAK1/4 inhibitor significantly reduced serum IL‐6 levels and liver tumours in STK4 KO mice to similar levels as those in wild‐type mice. Our study suggests STK4 as a biomarker for inflammation‐associated HCC. Support or Funding Information This work was supported by grants from the Ministry of Science and Technology of China (2012CB910800), National Natural Science Foundation of China (81571617, 81571552, 31070778, 81590764, 31370859, 31300723). Dr. H. W. is supported by the Hundred Talents Program of the Chinese Academy of Sciences.