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Effect of aqueous leaf extract of Pennisetum purpurem in alloxan‐induced diabetic wistar rats
Author(s) -
Omeodu Stephen Ike,
OnyegemeOkerenta Blessing Minaopunye
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1101.1
Subject(s) - alloxan , amylase , chemistry , body weight , pennisetum , aqueous extract , alanine aminotransferase , medicine , alanine transaminase , zoology , endocrinology , biochemistry , diabetes mellitus , traditional medicine , enzyme , biology , botany
Some biochemical indices (aspartate aminotransferase [AST], alanine aminotransferase [ALT], total protein, amylase and glucose) were evaluated in alloxan‐induced diabetic wistar rats treated with aqueous leaf extract of Pennisetum purpurem. Sixteen wistar albino rats were grouped into four. Group 1 served as the control while Groups 2 – 4 were administered with 120 mg/kg body weight alloxan – a toxic glucose analogue that resulted in a hyperglycemic state. Group 2 did not receive any treatment and served as the negative control. Groups 3 and 4 were treated with 1200 and 1500 mg/kg body weight aqueous extract of P. purpurem respectively for seven days and thereafter, the rats were sacrificed and the effects of the plant extract on the liver investigated. Results showed that there was significant reduction (p<0.05) in AST, ALT and glucose levels when groups treated with 1200 and 1500 mg/kg body weight aqueous extract of P. purpurem were compared with the control group. On the other hand, there was no significant reduction in amylase and Total protein concentration (p>0.05) when the group treated with 1200 mg/kg body weight extract of P. purpurem was compared with the control group. However, there was significant reduction (p<0.05) in amylase and Total protein concentration when the group treated with 1500 mg/kg body weight aqueous extract of P. purpurem was compared with the control group. This study shows that the aqueous extract of P. purpurem caused a significant reduction in serum glucose, AST, ALT, amylase and total protein in alloxan‐induced diabetic rats. Support or Funding Information Research was funded by the authors.