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Mechanisms and Physiology of Fat Synthesis and Storage
Author(s) -
Farese Robert V.
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.109.1
Subject(s) - lipid droplet , organelle , chemistry , lipid metabolism , cytosol , microbiology and biotechnology , biochemistry , biophysics , enzyme , biology
The synthesis and storage of neutral lipids, such as triglycerides, are crucial for both cellular and physiological energy homeostasis. When fuels are abundant, triglycerides are synthesized in the ER by DGAT enzymes and subsequently stored in cytosolic organelles called lipid droplets. We study the molecular processes that govern the synthesis of energy storage lipids as well as their storage in and mobilization from lipid droplets. Studies on genetic factors controlling lipid droplet growth and utilization will be presented, as will relevant studies of the physiology of lipid storage.