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Precise Redox Responses Imprinted by On‐Demand Redox Targeting
Author(s) -
Aye Yimon
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1088.1
Subject(s) - redox , second messenger system , proteome , small molecule , crosstalk , chemistry , microbiology and biotechnology , nanotechnology , computational biology , biology , biophysics , biochemistry , bioinformatics , signal transduction , materials science , physics , organic chemistry , optics
Chemical redox signals are an emerging class of small‐molecule messengers believed to be essential for nearly all aspects of life. However, the mechanisms by which regulated redox events on a specific target elicit specific physiologic responses is unknown because the existing tools to interrogate redox perturbation are not specific. Our laboratory developed a unique platform—T‐REX ( t argetable r eactive e lectrophiles and o x idants), with which specific sensor proteins can be selectively modified with a choice of >10 specific redox signal on demand against an otherwise unperturbed proteome. T‐REX is validated to (1) pinpoint the precise impacts of reactive small‐molecule messengers on specific signaling nodes at the level of timing and specificity inaccessible with current tools, and (2) identify bona fide redox‐sensor targets of disease relevance. This talk highlights some of our latest findings underpinning the specific chemical redox signaling events of major therapeutic significance. Support or Funding Information We acknowledge the research support from the Cornell University & Weill Cornell Medical College, NIH Director's new innovator, NSF CAREER, the Beckman Young Investigator, and the Burroughs Wellcome Fund grant programs.T‐REX On‐Demand Redox Targeting