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A new approach to characterize the molecular interactions between TiO 2 nanoparticles and dietary flavonoids using surface‐enhanced Raman spectroscopy
Author(s) -
Cao Xiaoqiong,
Gao Zili,
Zheng Jinkai,
He Lili,
Xiao Hang
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1082.9
Subject(s) - nanoparticle , myricetin , quercetin , chemistry , apigenin , kaempferol , luteolin , raman spectroscopy , nanotechnology , flavonoid , mxenes , materials science , organic chemistry , physics , optics , antioxidant
TiO 2 nanoparticles are commonly presented in food additives (E171), and have been associated with potential adverse effects on health. TiO 2 nanoparticles has a specific surface reactivity and bind bidentate ligands from the environment. Flavonoids are widely found in fruits and vegetables, and can act as electro‐donating agents for TiO 2 nanoparticles. Knowledge on the molecular interactions between TiO 2 nanoparticles and food components such as flavonoid compounds will facilitate the understanding of the fate of TiO 2 nanoparticles in food and in the gastrointestinal tract. In this study, we utilized surface‐enhanced Raman spectroscopy (SERS) to develop a rapid and accurate characterization method for the interactions between TiO 2 nanoparticles and flavonoids. TiO 2 anatase nanoparticles were mixed with seven different flavonoids (i.e. apigenin, luteolin, fisetin, kaempferol, quercetin, myricetin and baicalin) to form a complex that was subjected to SERS analysis. Our results demonstrated that the complex produced distinctive SERS ‘fingerprints’, which allowed further analysis of the molecular interaction. Phenolic groups in the flavonoids played pivotal roles in the interaction between flavonoids and TiO 2 nanoparticles. Difference in the numbers and positions of the phenolic groups contributed to the distinctive SERS spectra of different complex. There is no report has been found on the application of SERS in studying the interactions between TiO 2 nanoparticles and dietary flavonoids. We successfully developed a simple and accurate SERS‐based method to characterize the molecular interaction between TiO 2 nanoparticles and various dietary flavonoid compounds. Support or Funding Information This study was partially support by fund from USDA.