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Using Rabbit Umbilical Cord Stem Cells as Vehicle to Deliver Anti‐Cancer Drugs to Treat Pancreatic Cancer
Author(s) -
Marolt Clayton,
Rachakatla Raja Shekar
Publication year - 2016
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.30.1_supplement.1036.6
Subject(s) - pancreatic cancer , medicine , cancer , cancer cell , stem cell , cancer stem cell , umbilical cord , in vivo , cancer research , immunology , biology , microbiology and biotechnology
Pancreatic cancer is one of the deadliest and most aggressive forms of cancer, with a five‐year survival rate after diagnosis of 6.7%. There are numerous treatments available, but none are able to effectively target the cancer cells directly without harming nearby healthy cells, causing unwanted side effects to the patient. The objective of this study is to determine how effective rabbit umbilical cord stem cells (rUCSC) are at targeting Pan02 pancreatic cancer cells and delivering interferon‐β (IFN‐β) to kill the cancer cells in vitro . We investigated the trophic ability of rUCSC towards Pan02 cells. This study showed that as Pan02 cell concentration increased, the amount of stem cell migration increased as well. We then investigated the anti‐cancer ability of rUCSC‐IFN‐β on Pan02 cells as compared to regular rUCSC. Pan02 cells both alive and dead were counted. This study showed that wells with rUCSC‐IFN‐β had higher amounts of dead Pan02 cells compared to the control wells with rUCSCs. These results indicate the trophic ability of rUCSCs and the use as a drug delivery vehicle through the anti‐cancer ability of IFN‐β. Future studies include testing rUCSC‐IFN‐β's efficacy on pancreatic cancer in vivo in SCID mouse models.