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Effects of sleep deprivation on human immune functions
Author(s) -
Moldofsky H.,
Lue F. A.,
Davidson J. R.,
Gorczynski R.
Publication year - 1989
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.3.8.2785942
Subject(s) - sleep deprivation , pokeweed mitogen , circadian rhythm , endocrinology , immune system , medicine , sleep (system call) , wakefulness , nocturnal , stimulation , privation , biology , immunology , neuroscience , in vitro , peripheral blood mononuclear cell , electroencephalography , biochemistry , computer science , operating system
The effect of 40 h of wakefulness on a variety of immunological parameters in the peripheral blood from 10 normal male subjects was studied. Sleep deprivation led to enhanced nocturnal plasma interleukin 1‐like and interleukin 2‐like activities. The rise in nocturnal response of lymphocytes to pokeweed mitogen stimulation during a normal 24 h sleep‐wake cycle was delayed by sleep deprivation, but the response to the phytohemagglutinin mitogen was unaffected. With resumed nocturnal sleep, there was a prolonged decline in natural killer cell activity (measured as spontaneous cytolytic activity for human tumor cells) and return of an increased response to pokeweed mitogen. The altered patterns in immune functions occurred independently of the Cortisol circadian rhythm, which remained unchanged.—M oldofsky , H.; L ue , F. A.; D avidson , J. R.; G orczynski , R. Effects of sleep deprivation on human immune functions. FASEB J. 3: 1972‐1977; 1989.