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Brevetoxins: unique polyether dinoflagellate toxins
Author(s) -
Baden Daniel G.
Publication year - 1989
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.3.7.2565840
Subject(s) - dinoflagellate , geology , oceanography
Brevetoxins are lipid‐soluble polyether marine toxins of unique structure and pharmacological function. Toxins are active in vivo in the nanomolar to picomolar concentration range and in vitro in isolated neuromuscular or giant axon preparations and in single‐cell or subcellular model systems. Their effect is excitatory, mediated by the enhancement of cellular Na + influx. Brevetoxins bind at site 5 on the voltage‐sensitive sodium channel, a specificity shared with ciguatoxin. This site is allosterically linked to other natural toxin binding sites on the channel.—B aden , D. G. Brevetoxins: unique polyether dinoflagellate toxins. FASEB J. 3: 1807‐1817; 1989.