Premium
Glyoxylate cycle in the rat liver: effect of vitamin D 3 treatment
Author(s) -
Davis Walter L.,
Matthews James L.,
Goodman David B. P.
Publication year - 1989
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.3.5.2537775
Subject(s) - glyoxylate cycle , malate synthase , isocitrate lyase , peroxisome , vitamin , biochemistry , glycogen , enzyme , medicine , endocrinology , malate dehydrogenase , chemistry , biology , gene
Evidence for the glyoxylate cycle in the mammalian rat liver was sought. Activity of two unique glyoxylate cycle enzymes, isocitrate lyase and malate synthase, was found in rat liver homogenates. Vitamin D 3 treatment of rachitic animals produced a five‐ and fourfold increase, respectively, in the activity of these enzymes. Vitamin D 3 also increased the peroxisomal fatty acid oxidation and the accumulation of glycogen in liver slices in the presence of palmitate. These data suggest that the mammalian rat liver can convert fatty acid carbon to carbohydrate carbon directly.—D avis , W. L.; M atthews , J. M.; G oodman , D. B. P. Glyoxylate cycle in the rat liver: effect of vitamin D 3 treatment. FASEB J. 3: 1651‐1655; 1989.