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Glutathione metabolism at the blood‐cerebrospinal fluid barrier
Author(s) -
Anderson Mary E.,
Underwood Mark,
Bridges Richard J.,
Meister Alton
Publication year - 1989
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.3.13.2572501
Subject(s) - glutathione , choroid plexus , cerebrospinal fluid , chemistry , metabolism , biochemistry , buthionine sulfoximine , endocrinology , medicine , biology , central nervous system , enzyme
Glutathione metabolism and transport in the choroid plexus were probed by determining the effects of administration to rats of several compounds (buthionine sulfoximine, L‐2‐oxothiazolidine‐4‐carboxylate, L‐(α5,5S)‐α‐amino‐3‐chloro‐4,5‐dihydro‐5‐isoxazole acetic acid, γ‐glutamyl alanine, and glutathione monoethyl ester) on the levels of glutathione and cysteine in the cerebrospinal fluid. The findings indicate that glutathione is actively metabolized in the choroid plexus by pathways similar to those in kidney and other tissues. The level of glutathione in the cerebrospinal fluid can be decreased or increased by giving compounds that do not, under similar conditions, appreciably alter total brain levels of glutathione. Glutathione monoethyl ester is effectively transported into the cerebrospinal fluid.—A nderson , M. E.; U nderwood , M.; B ridges , R. J.; M eister , A. Glutathione metabolism at the blood‐cerebrospinal fluid barrier. FASEB J. 3: 2527‐2531; 1989.

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