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Neutralization of small RNA viruses by antibodies and antiviral agents 1
Author(s) -
Rossmann Michael G.
Publication year - 1989
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.3.12.2676677
Subject(s) - rna , virology , neutralization , virus , biology , antibody , host (biology) , viral evolution , chemistry , genetics , gene
The 3‐dimensional structures of a number of small animal RNA viruses are now known to near‐atomic resolution. All these viruses have similar structures and have, in all probability, diverged from a common ancestral virus able to infect a variety of organisms. The structures have elucidated the site of attachment to host cell receptors and the mode of protection of this site against host immune pressure. An internal hydrophobic pocket in rhinoviruses is the site for binding of antiviral drugs that inhibit uncoating and can inhibit attachment in some viruses. The pocket is probably a functional necessity, and thus is a suitable target for well‐designed antiviral agents in many viruses.— R ossmann , M. G. Neutralization of small RNA viruses by antibodies and antiviral agents. FASEB J. 3: 2335‐2343; 1989.