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5‐Hydroxytryptamine receptor “families”
Author(s) -
Schmidt Anne W.,
Peroutka Stephen J.
Publication year - 1989
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.3.11.2673898
Subject(s) - receptor , radioligand , biology , 5 ht5a receptor , identification (biology) , 5 ht receptor , computational biology , molecular pharmacology , enzyme linked receptor , pharmacology , genetics , serotonin , ecology
The identification of multiple receptor subtypes for 5‐hydroxytryptamine (5‐HT) made by using radioligand binding techniques proliferated at a brisk rate in the 1980s. The application of molecular biological techniques to 5‐HT receptor studies is likely to lead to an expansion rather than a reduction in the number of distinct 5‐HT receptor subtypes. Although the current status of 5‐HT receptor pharmacology may appear to be overwhelmingly confusing to most investigators, the evolving data suggest that 5‐HT receptor subtypes can be categorized into three major families. Each family consists of multiple receptor subtypes that share similarities in their molecular biological, pharmacological, biochemical, and/or physiological properties. This review provides a summary of recent data as well as a framework for the classification of 5‐HT receptor subtypes.— S chmidt , A. W.; P eroutka , S. J. 5‐Hydroxytryptamine receptor “families.” FASEB J. 3: 2242‐2249; 1989.