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Role of glucocorticoids in the regulation of lipogenesis
Author(s) -
Berdanier Carolyn D.
Publication year - 1989
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.3.10.2666232
Subject(s) - anabolism , lipogenesis , glucocorticoid , catabolism , glucocorticoid receptor , stimulation , endocrinology , hormone , medicine , anabolic agents , biology , chemistry , lipid metabolism , metabolism
Traditionally, the glucocorticoids have been viewed as catabolic hormones. However, with the present knowledge about how the glucocorticoid receptor protein functions in the stimulation of mRNA synthesis, a new view must be accepted: These steroids also have an anabolic function. They are anabolic because they stimulate the de novo synthesis of enzymes of anabolic pathways. In the liver, stimulation of lipogenic enzymes has been shown. These findings suggest that glucocorticoids can increase feed efficiency and thereby play a role in the etiology of obesity.— B erdanier , C. D. Role of glucocorticoids in the regulation of lipogenesis. FASEB J. 3: 2179‐2183; 1989.