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Plasticity of neuronal receptors
Author(s) -
Klein William L.,
Sullivan James,
Skorupa Annette,
Aguilar J. Santiago
Publication year - 1989
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.3.10.2546848
Subject(s) - receptor , neuroscience , biology , plasticity , neuroplasticity , synapse , synaptic plasticity , microbiology and biotechnology , physics , biochemistry , thermodynamics
This article describes ways in which receptors, key components of signal propagation through a synapse, can mediate changes in that propagation. Changes occur at four levels: in the signal‐transducing capability of a single receptor molecule, in the number of receptors per cell, in the subcellular placement of receptor molecules, and in the cytoarchitecture of receptor‐rich regions. The ability of receptors to shift betewen different desired states is called plasticity, and such shifts can be long‐lived as well as transient. In this article we focus on neuronal receptors, although key findings from a variety of cell systems are reported. Neuronal receptor plasticity may have a special role in the assembly as well as the adaptability of the nervous system.— K lein , W. L.; S ullivan , J.; S korupa , A.; A guilar , J. S. Plasticity of neuronal receptors. FASEB J. 3: 2132‐2140; 1989.