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Respiratory Control in Female Adult Rats
Author(s) -
Silva Glauber,
Marques Danuzia,
Carvalho Débora,
Bícego Kênia,
Gargaglioni Luciane
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.lb743
Subject(s) - estrous cycle , ovariectomized rat , medicine , endocrinology , hypoxia (environmental) , hormone , respiratory system , tidal volume , ventilation (architecture) , respiratory minute volume , biology , oxygen , chemistry , mechanical engineering , organic chemistry , engineering
Sex hormones may influence many physiological processes. It is still unclear whether sex hormones and hormonal fluctuations that occur during the estrous cycle can affect respiratory control. Our study aimed to evaluate the ventilatory responses to hypoxia in female adult rats. To do so, we measured ventilation (V E ), tidal volume (V T ), respiratory frequency (fR), oxygen consumption (VO 2 ) and body temperature (Tc) of female rats at different stages of estrous cycle (proestrus, estrus, metaestrus and diestrous) and ovariectomized (OVX) female rats during normoxia (21%O 2 ) and hypoxia (7% O 2 ). V E , V T , fR, VO 2 and V E /VO 2 were not different among animals in different stages of the estrous cycle in normoxia and hypoxia. However, Tc was higher in female rats in estrus. Hormone replacement in females did not change the ventilatory and metabolic parameters. However, females OVX, OVX + E2 and OVX + EP showed a lower ventilatory response to hypoxia compared with intact females in estrus. Thus, our data suggest that the different phases of the estrous cycle did not alter ventilation in normoxia and hypoxia. OVX animals presented an attenuated response to hypoxia. Hormone replacement with E2 or P4 did not cause significant difference in hypoxic ventilatory response. Our data suggest that other gonadal factors might be involved in the process. Financial Support: FAPESP